Below are papers that were authored by P3 Cohort team members (names are bolded) in the last six years related to the prediction, prevention and intervention for preterm birth and the health of preterm infants and children.


Han YC, Laketic K, Hornaday KK, Slater DM, Mu C, Tough SC, Shearer, J.  2024. Maternal Acylcarnitine Disruption as a Potential Predictor of Preterm Birth in Primigravida: A Preliminary Investigation. Nutrients 16(5):595. 

Lodha Ar, Moser J, Walker A, Lodha Ab, Tang S, McAllister D. 2024. Association of epidural analgesia in labor with neurodevelopmental outcomes in premature infants born at <29 weeks of gestational age. J Perinatol. 44(4):548-553.

Okun N, Hoffman B, Johnson JA, Biringer A, Shapiro J, Felix C, Van Meighem T, Abassi N, Metcalfe A, Maxey C, Snelgrove JW. 2024. Implementation of multiple marker screening for preterm preeclampsia in single tertiary obstetric centre. JOGC 46(1):102220.


Abou Mehrem, A., Toye, J., Aziz, K., Benzies, K., Alshaikh, B., Johnson, D., Faris, P., Soraisham, A., McNeil, D., Al Hamarneh, Y. N., Foss, K., Foulston, C., Johns, C., Zimmermann, G. L., Zein, H., Hendson, L., Kumaran, K., Price, D., Singhal, N., & Shah, P. S. 2023. Alberta Collaborative Quality Improvement Strategies to Improve Outcomes of Moderate and Late Preterm Infants (ABC-QI) Trial: a protocol for a multicentre, stepped-wedge cluster randomized trial. CMAJ Open, 11(3), E397–E403.

Calvert C, Brockway MM, Zoega H et al 2023. Changes in preterm birth and stillbirth during COVID-19 lockdowns in 26 countries. Nat Hum Behav. 2023 Feb 27.

Chaput KH, Freeman M, McMorris C, Metcalfe A, Cameron EE, Jung J, Tough S, Hicks LM, Dimidjian S, Tomfohr-Madsen LM. 2023. Effect of Remote Peer-Counsellor- delivered Behavioral Activation and Peer-support for Antenatal Depression on Gestational Age at Delivery: a single-blind, randomized control trial. Trials 2023 Mar 30;24(1):240.

Johnson J, Walsh J, Pastuck M, Metcalfe A, Maxey CM, Soliman N, Mahallati H, Kuret VH, Dwinnell SJ, Chadha R, O’Quinn CP, Schachar J, Somerset DA, Paterson K, Suchet IB, Silang KA, Paul H, Nerenberg K, Okun NB, Johnson DW. 2023. The implementation of preeclampsia screening and prevention (IMPRESS Study). Am J Obstet Gynecol MFM 5(2):100815.

Journault M, Murthy P, Bensal N, Tang S, Al Awad E, Creighton D, Newman J, Lodha A. 2023. The association of maternal overweight on long-term neurodevelopmental outcomes in premature infants (<29 weeks) at 18-24 months corrected age. J Perinatol. 43(11):1413-1419.

King R, Low S, Gee N, Wood R, Hadweh B, Houghton J, Leijser LM. 2023. Practical Stepwise Approach to Performing Neonatal Brain MR Imaging in the Research Setting. Children (Basel) 10(11):1759

Lee S, Seow CH, Nerenberg K, Bertazzon S, Leung Y, Huang V, Whitten T, Coward S, Panaccione R, Kaplan GG, Metcalfe A. 2023. Despite Increased Disease Activity, Women who Attended a Dedicated Inflammatory Bowel Disease and Pregnancy Clinic Had Infants with Higher Apgar Scores: A Population-Based Study. Inflammatory Bowel Diseases, izad147.

Matenchuk BA, Rosychuk R, Rowe BH, Metcalfe A, Chari R, Crawford S, Jelinski S, Serrano-Lomelin J, Ospina MB. 2023. Emergency department visits during pregnancy. Annals of Emergency Medicine 81(2): 197-208

Srajer A, Roychoudhury S, Tang S, Hasan S, Momin S, Hendson L, Alshaikh B, Yusuf K. 2023. Postnatal acetaminophen exposure and neurodevelopmental outcomes at 18–21 months corrected gestational age in preterm infants <29 weeks gestation: a retrospective cohort study. Pediatric research, 10.1038/s41390-023-02901-x.

Stephenson N, Tough S, Williamson T, McDonald S, McMorris C, Metcalfe A. 2023. Early childhood trajectories of domain-specific developmental delay and gestational age at birth: an analysis of the All Our Families cohort. PLOS One 18(12):e0294522.

Thomas S, Jain S, Murthy P, Joseph C, Soraisham A, Tang S, Dosani A, Lodha A. 2023. Neurodevelopmental outcomes of premature infants born <29 weeks with bronchopulmonary dysplasia-associated pulmonary hypertension: A multicenter study. American Journal of Perinatology, 10.1055/a-2121-8878. 

Wasylak T, Benzies K, McNeil D, Zanoni P, Osiowy K, Mullie T, Chuck A. 2023. Creating Value Through Learning Health Systems: The Alberta Strategic Clinical Network Experience. Nursing administration quarterly, 47(1), 20–30.

 Xie EB, Jung JW, Kaur J, Benzies KM, Tomfohr-Madsen L, Keys E. 2023. Digital Parenting Interventions for Fathers of Infants from Conception to the Age of 12 Months: Systematic Review of Mixed Methods Studies. J Med Internet Res. 25:e43219.


Benlamri A, Murthy P, Zein H, Thomas S, Scott JN, Abou Mehrem A, Esser M, Lodha A, Noort J, Tang S, Metcalfe C, Kowal D, Irvine L, Scotland J, Leijser LM, Mohammad K. 2022. Neuroprotection care bundle implementation is associated with improved long-term neurodevelopmental outcomes in extremely premature infants. J Perinatol 42, 1380–1384.

Cairncross ZF, Couloigner I, Ryan MC, McMorris C, Muehlenbachs L, Nikolaou N, Wong RC, Hawkins SM, Bertazzon S, Cabaj J, Metcalfe A. 2002. Association Between Residential Proximity to Hydraulic Fracturing Sites and Adverse Birth Outcomes. JAMA Pediatr. 2022 Apr 4. 

Felske L, Castillo E, Kuret V, Metcalfe A. 2022. Comparing adverse neonatal and maternal outcomes of sexually transmitted infections and co-infections in pregnancy: a cross-sectional study. Paediatric and Perinatal Epidemiology 36(4):556-565

Grant-Orser A, Metcalfe A, Pope JE, Johannson KA. 2022. Pregnancy Considerations for Patients With Interstitial Lung Disease. Chest. 162(5):1093-1105.

Gurram Venkata SKR, Srivastava A, Murthy P, Scott JN, Zein H, Leijser L, Ghosh A, Momin S, Thomas S, Mohammad K. 2022. Hemodynamic Quality Improvement Bundle to Reduce the Use of Inotropes in Extreme Preterm Neonates. Paediatr Drugs 24(3):259-267. 

Hornaday KK, Wood EM, Slater DM. 2022. Is there a maternal blood biomarker that can predict spontaneous preterm birth prior to labour onset? A systematic review. PLoS One. 2022 Apr 4;17(4):e0265853. 

Koch AK, Burger RJ, Schuit E, Fernando Mateus J, Goya M, Carreras E, Bianocolin S, Barzilay E, Soliman N, Cooper S, Metcalfe A, Lodha A, Fichera A, Stagnati V, Kawamura H, Rustico M, Munim S, Russo F, Nassar A, Rode L, Lim A, Liem S, Grantz K, Hack K, Tang S, Combs A, Serra V, Perales A, Khalil A, Barrett J, Ganzevoort W, Gordign SJ, Morris RK, Mol BW, Li W. 2022. Timing of delivery for twins affected by growth discordance and growth restriction: an individual participant data meta-analysis. In press Obstetrics and Gynecology. 

Krüse-Ruijter MF, Boswinkel V, Consoli A, Nijholt IM, Boomsma MF, de Vries LS, van Wezel-Meijler G, Leijser LM. 2022. Neurological Surveillance in Moderate-Late Preterm Infants—Results from a Dutch–Canadian Survey. Children 9(6):846.

Lithgow K, Buchholz V, D’Aubeterre A, Ku E, Konschuh S, and Sycuro LK. 2022. Protease activities of vaginal Porphyromonas species disrupt coagulation and extracellular matrix in the cervicovaginal niche. npj Biofilms & Microbiomes, 2022; 8(1):8. 

Matenchuk BA, Rosychuk RJ, Rowe BH, Metcalfe A, Chari R, Crawford S, Jelinski S, Serrano-Lomelin J, Ospina MB. 2022. Emergency department visits during the postpartum period: A Canadian cohort study. In press. Annals of Emergency Medicine.

Mohammad K, Momin S, Murthy P, Zein H, Scott JN, Mehrem AA, Ghosh A, Javadyan A, Awad EA, Venkata SKRG, Paul R, Rombough B, Bolderheij L, Dossani S, Montpetit J, Eshemokhai P, Fiedrich E, Thomas S. 2022. Impact of quality improvement outreach education on the incidence of acute brain injury in transported neonates born premature. J Perinatol. 2022 May 4.

Pekarsky C, Skiffington J, Leijser LM, Slater D, Metcalfe A. 2022. Social Media Recruitment Strategies to Recruit Pregnant Women into a Longitudinal Observational Cohort Study: Usability Study. J Med Internet Res. 24(12):e40298.

Raffe-Devine J, Somerset DA, Metcalfe A, Cairncross ZF. 2022. Maternal, fetal, and neonatal outcomes of elective fetal reduction among multiple gestation pregnancies: a systematic review. JOGC 44(1): P60-P70.E12. 

Ringham C, McNeil D, Benzies KM. 2022. The Work of Mothering in the NICU: A Critical Analysis of Alberta Family Integrated Care Parent Journals. Adv Neonatal Care. 2022;22(4):E112-E119.

Shafey A, Benzies K, Amin R, Stelfox HT, Shah V. 2022. Fathers’ Experiences in Alberta Family Integrated Care: A Qualitative Study. J Perinat Neonatal Nurs. 36(4):371-379.

Tomfohr-Madsen LM, Roos LE, Madsen JW, Leason J, Singla DR, Charlebois J, Tomasi P, Chaput KH. 2022. Peer-Led Psychotherapy: The Time Is Now. J Clin Psychiatry. 83(3):21lr14366a.  


Adhikari K, Patten SB, Patel AB, Premji S, Tough S, Letourneau N, Giesbrecht G, Metcalfe A. 2021. Data Harmonization and Data Pooling from Cohort Studies: A Practical Approach for Data Management. International Journal of Population Data Science 6(1):1680. 

Adhikari K, Patten SB, Williamson T, Patel AB, Premji S, Tough S, Letourneau N, Giesbrecht G, Metcalfe A. 2021. Assessment of anxiety during pregnancy: are existing multiple anxiety scales suitable and comparable in measuring anxiety during pregnancy? Journal of Psychosomatic Obstetrics and Gynecology 42(2):140-146. 

Assis Z, Kirton A, Pauranik A, Sherriff M, Wei XC. Idiopathic Neonatal Subpial Hemorrhage with Underlying Cerebral Infarct: Imaging Features and Clinical Outcome. AJNR Am J Neuroradiol. 2021 Jan;42(1):185-193.

Dunbar MJ, Woodward K, Leijser LM, Kirton A. Antenatal diagnosis of fetal intraventricular hemorrhage: systematic review and meta-analysis. Dev Med Child Neurol. 2021 Feb;63(2):144-155.

Fenton TR, Nasser R, Creighton D, Tang S, Sauve R, Bilan D, Fenton CJ, Eliasziw M. Weight, length, and head circumference at 36 weeks are not predictive of later cognitive impairment in very preterm infants. J Perinatol. 2021 Mar;41(3):606-614. 

Hetherington E, Adhikari K, Tomfohr-Madsen L, Patten SB, Metcalfe A. 2021. Birth outcomes, pregnancy complications, and mental health after the 2013 Calgary flood: a difference in difference analysis. PLOS One 16(2): e0246670. 

MacKinnon AL, Madsen JW, Giesbrecht GF, Campbell T, Carlson LE, Dimidjian S. Letourneau N, Tough S, Tomfohr-Madsen L. Effects of Mindfulness-Based Cognitive Therapy in Pregnancy on Psychological Distress and Gestational Age: Outcomes of a Randomized Controlled Trial. Mindfulness. 2021. 

McNeil, DA, Benzies, KM, Zanoni, P, Kurilova J. Alberta Family Integrated Care (FICare)™: From engaged clinicians in a cluster randomized controlled trial to health system partnership in scale and spread across a province. In: McCutcheon C, Reszel J, Kothari A, Graham ID, editors. How We Work Together: The Integrated Knowledge Translation Research Network Casebook. 2021. Volume 4, 16-19. Ottawa, ON: Integrated Knowledge Translation Research Network. Available here.

Mitra S, Jain A, Ting JY, Ben Fadel N, Drolet C, Abou Mehrem A, Soraisham A, Jasani B, Louis D, Lapointe A, Dorling J, Khurshid F, Hyderi A, Kumaran K, Bodani J, Weisz D, Alvaro R, Adie M, Stavel M, Morin A, Bhattacharya S, Kanungo J, Canning R, Ye XY, Hatfield T, Gardner CE, Shah P. Relative effectiveness and safety of pharmacotherapeutic agents for patent ductus arteriosus (PDA) in preterm infants: a protocol for a multicentre comparative effectiveness study (CANRxPDA). BMJ Open. 2021 May 5;11(5):e050682. 

Mohammad K, Scott JN, Leijser LM, Zein H, Afifi J, Piedboeuf B, de Vries LS, van Wezel-Meijler G, Lee SK, Shah PS. Consensus Approach for Standardizing the Screening and Classification of Preterm Brain Injury Diagnosed With Cranial Ultrasound: A Canadian Perspective. Front Pediatr. 2021 Mar 8;9:618236. 

Nahirney M, Chaput K, Metcalfe A. Assessing the role of maternal race on the prediction of NICU admission by three neonatal growth standards: A Cross-Sectional Study. Journal of Maternal Fetal and Neonatal Medicine, 2021;34(8):1233-1240. 

Nieuwets A, Cizmeci MN, Groenendaal F, Leijser LM, Koopman C, Benders MJNL, Dudink J, de Vries LS, van der Aa NE. 2021.  Post-hemorrhagic ventricular dilatation affects white matter maturation in extremely preterm infants. Pediatr Res. 2021 Aug 26.

Qureshi M, Shah PS, Abdelgadir D, Ye XY, Afifi J, Yuen R, Crossman SC, Taylor B, Mohammad K, Piedboeuf B, Aziz K. Canadian Neonatal Network investigators. Gestational Age-Dependent Variations in Effects of Prophylactic Indomethacin on Brain Injury and Intestinal Injury. J Pediatr. 2021 Mar 7:S0022-3476(21)00216-X.

Ramage K, Tough S, Scott C, McLaughlin AM, Metcalfe A. 2021. Trends in adolescent rapid repeat pregnancy in Canada. Journal of Obstetrics and Gynecology Canada 43(5):589-595.

Roychoudhury S, Lodha A, Synnes A, Abou Mehrem A, Canning R, Banihani R, Beltempo M, Theriault K, Yang J, Shah PS, Soraisham AS. 2021. Canadian Neonatal Network; Canadian Preterm Birth Network; Canadian Neonatal Follow-Up Network Investigators. Neurodevelopmental outcomes of preterm infants conceived by assisted reproductive technology. Am J Obstet Gynecol. 225(3):276.e1-276.e9.

Scime NV, Metcalfe A, Nettel-Aguirre A, Tough SC, Chaput KH. 2021. Association of prenatal medical risk with breastfeeding outcomes up to 12 months in a community-based birth cohort. International Breastfeeding Journal 16:69. 

Wood EMHornaday KKSlater DM (2021) Prostaglandins in biofluids in pregnancy and labour: A systematic review. PLOS ONE 16(11): e0260115.

Zein H, Mohammad K, Leijser LM, Brundler MA, Kirton A, Esser MJ. Cord Blood Cytokine Levels Correlate With Types of Placental Pathology in Extremely Preterm Infants. Front Pediatr. 2021 Mar 11;9:607684. 


Adhikari K, Patten SB, Williamson T, Patel AB, Premji S, Tough S, Letourneau N, Giesbrecht G, Metcalfe ANeighbourhood socioeconomic status modifies the association between anxiety and depression during pregnancy and preterm birth: a community-based Canadian cohort study. BMJ Open 2020; 10:e031035. 

Benzies KM, Aziz K, Shah V,  Isaranuwatchai W, Scotland J, Larocque J, Mrklas KJ, Naugler C, Stelfox HT, Chari R, Soraisham A, Akierman AR, Phillipos E, Amin H, Hoch J, Zanoni P, Kurilova J, Lodha A, the Alberta Family Integrated Care (FICare) Team. Effectiveness of Alberta Family Integrated Care (FICare) in Level II Neonatal Intensive Care Units (NICU) on infant and maternal outcomes: a provincial, pragmatic, cluster randomized controlled trial. BMC Pediatrics, 2020; 20:535. 

Brockway, M, Benzies, KM, Carr E, Aziz K. Does breastfeeding self-efficacy theory apply to mothers of moderate and late preterm infants? A qualitative exploration. Journal of Clinical Nursing 2020; 29, 2872–2885.

Cairncross ZF, Chaput KH, McMorris C, Ospina M, Brown HK, Metcalfe A. Roles of the underlying cause of delivery and gestational age on long-term child health. Paediatric and Perinatal Epidemiology, 2020; 34(3):331-340.

Cizmeci MN, de Vries LS, Ly LG, van Haastert IC, Groenendaal F, Kelly EN, Traubici J, Whyte HE, Leijser LM. Periventricular Hemorrhagic Infarction in Very Preterm Infants: Characteristic Sonographic Findings and Association with Neurodevelopmental Outcome at Age 2 Years. J Pediatr. 2020; Feb;217:79-85.e1. 

Jijon H, Ueno A, Sharifi N, Leung Y, Ghosh S, Seow CHElevated interferon-gamma levels during pregnancy are associated with adverse maternofetal outcomes in IBD. Gut. 2020 Oct;69(10):1895-1897. 

Leijser LM, Scott JN, Roychoudhury S, Zein H, Murthy P, Thomas SP, Mohammad K; Calgary Neonatal Neuro-Critical Care Program. Post-hemorrhagic ventricular dilatation: inter-observer reliability of ventricular size measurements in extremely preterm infants. Pediatr Res. 2020 Nov 12. 

Mackay L, Benzies K, Barnard C, Raffin Bouchal S. 2020. Health Care Professionals’ Experiences of Providing Care to Hospitalized Medically Fragile Infants and Their Parents. J Pediatr Nurs. 53:14-21. 

Mohammad K, Murthy P, Aguinaga F, Fajardo C, Eguiguren L, Castro Y, Guzman V, Scott JN, Chan S, Soraisham A, Stritzke A, Al Awad E, Kamaluddeen M, Thomas S. Sonographic Clinical Assessment of the Newborn Group. Simulation-Based Structured Education Supports Focused Neonatal Cranial Ultrasound Training. J Ultrasound Med. 2020 Jun;39(6):1195-1201. 

Murthy P, Zein H, Thomas S, Scott JN, Abou Mehrem A, Esser MJ, Lodha A, Metcalfe C, Kowal D, Irvine L, Scotland J, Leijser L, Mohammad K. Neuroprotection Care Bundle Implementation to Decrease Acute Brain Injury in Preterm Infants. Pediatr Neurol. 2020 Sep;110:42-48. 

Ross KM, Carroll JE, Horvath S, Hobel CJ, Coussons-Read ME, Dunkel Schetter C. Epigenetic age and pregnancy outcomes: GrimAge acceleration is associated with shorter gestational length and lower birthweight. Clin Epigenetics. 2020 Aug 6;12(1):120. 

Scime N, Chaput KH, Farris P, Quan H, Tough SC, Metcalfe A. Pregnancy complications and risk of preterm birth according to maternal age: a population-based study of delivery hospitalizations in Alberta. Acta Obstétrica Gynocologica Scandinavica 2020; 99(4):459-468. 

Young JM, Vandewouw MM, Whyte HEA, Leijser LM, Taylor MJ. Resilience and Vulnerability: Neurodevelopment of Very Preterm Children at Four Years of Age. Front Hum Neurosci. 2020 Jul 14;14:219. 


Adhikari K, Patten SB, Williamson T, Patel AB, Premji S, Tough S, Letourneau N, Giesbrecht G, Metcalfe A. Does neighbourhood socioeconomic status predict the risk of preterm birth? A community-based Canadian cohort study. BMJ Open 2019; 9:e025341. 

Leijser LM, de Vries LS. Preterm brain injury: Germinal matrix-intraventricular hemorrhage and post-hemorrhagic ventricular dilatation. Handb Clin Neurol. 2019;162:173-199. doi: 10.1016/B978-0-444-64029-1.00008-4. PMID: 31324310.

Ross KM, Carroll JE, Dunkel Schetter C, Hobel C, Cole SW. Pro-inflammatory immune cell gene expression during the third trimester of pregnancy is associated with shorter gestational length and lower birthweight. Am J Reprod Immunol. 2019 Dec;82(6):e13190.

Ross KM, Dunkel Schetter C, McLemore MR, Chambers BD, Paynter RA, Baer R, Feuer SK, Flowers E, Karasek D, Pantell M, Prather AA, Ryckman K, Jelliffe-Pawlowski L. Socioeconomic Status, Preeclampsia Risk and Gestational Length in Black and White Women. J Racial Ethn Health Disparities. 2019 Dec;6(6):1182-1191. 

Tomfohr-Madsen L, Cameron EE, Dunkel Schetter C, Campbell T, O’Beirne M, Letourneau N, Giesbrecht GF. Pregnancy anxiety and preterm birth: The moderating role of sleep. Health Psychol. 2019 Nov;38(11):1025-1035.